Invokana (canagliflozin) is a medication which works by stopping glucose from being reabsorbed into the blood and allow patients to pass excess blood glucose through urination. Invokana was approved on March 29, 2013 by U.S Food and Drugs Administration. The drug is also known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. However, in May 2015 the agency issued a drug safety communication that Invokana and Invokamet may be linked to an increased risk of ketoacidosis. If left untreated, this condition can be fatal. As of yet, the FDA is telling patients to continue treatment unless they have a known susceptibility to any of canagliflozin’s risk factors. However, until more is known, people will likely continue to be severely harmed by the treatment.
Invokana “CANVAS” Clinical Trial Result
Recently few months back on 18th May the U.S. Food and Drug Administration have issued a new safety warning to the public regarding the Invokana Link with an approximately two-fold risk for Foot and Toe Amputation. According to an ongoing Clinical Trial Invokana medications cause Higher Risk of Amputation to the diabetic patients. In the safety warning the agency states that they are investigating to figure out new information and will provide more advice to the public once it is available. According to the CANVAS ongoing clinical trial the incidence of lower limb amputation are 7 per 1000 patient-years in the canagliflozin 100 mg group and 5 per 1000 patient-years in the canagliflozin 300 mg group, compared with 3 per 1000 patient-years who were given a placebo (a dummy treatment). As per the Independent Data Monitoring Committee for CANVAS and another study CANVAS-R has approved that the trials should continue. However, the panel determined an increased risk of leg and foot amputations in diabetic patient who are under Invokana medication.
How Invokana causes Foot and Toe Amputation?
Manufacturers and marketers present Invokana in market to provide cure for Type 2 diabetes that if not treated properly increase the risk for various serious problems such as high blood pressure, nerve damage, heart disease, gastro paresis, blindness, foot complications, kidney failure, stroke and etc. Invokana medication damage the blood vessels and nerves in the body which decreases the blood circulation level in the diabetic patient due to which serious infections occurs that are extremely hard to treat that lead to removal of a leg, foot or toes from the body that is called Leg or foot amputation. According to the Canagliflozin Cardiovascular Assessment Study, the amputations occur approximately twice as often in patients taking Invokana as compared with those who took a placebo. Patients who developed Foot and Toe Amputation after taking the drugs filed invokana lawsuits claiming the drug manufacturers Fails to warn patients of the risks associated with Invokana. The plaintiff accuses the company of manufacturing a defective drug.
Foot and Toe Amputation Symptoms and Prevention
Diabetic patients are prone to having foot problems. Foot injuries and foot ulcer are the most common symptoms which causes Foot and Toe Amputation. It’s also the most common reason that someone’s going to be hospitalized with diabetes. There are some more symptoms predispose ulceration and ultimately amputation includes Infections spread rapidly, cold skin, Poor blood flow, chronic pain and Injury hard to heal. There are many prevention measures to avoid Foot and Toe Amputation includes stop smoking as it’s a major factor in diabetic foot disease. Make a routine to properly trimmed toenails to avoid infections and have a routine blood sugar level check up.
Any patient who was prescribed Invokana and suffered from Foot and Leg Amputation contact Drugsclaim .The Drugsclaim Lawyers and Attorneys are investigating claims that Invokana may be linked to kidney failure, cardiovascular complications, Foot and Leg Amputation and bone fractures. We have an experience team of Invokana injury lawyers to handle and evaluate the claim. They are prepared to help you and your family gets the compensation you deserve and that is free of cost till we win your case.
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